The Swiss league leaders will be without both Murat Yakin and Christian Gimenez as they try and overturn a 3-2 deficit, but their absence didn’t appear to affect the side's domestic form too much on Sunday as they cruised to a 5-2 victory over Grasshoppers.
Basel boss Christian Gross confirmed: "Murat Yakin and Gimenez won't play in Newcastle, they have got no chance.
"It is a major blow to us. We have already got a lot of work to do, and we didn't need this."
Cameroon international Timothee Atouba is though expected to be fit, despite missing the Grasshoppers game.