Brentford will be roared on at Newcastle by close to 3,000 fans with 2,655 tickets already sold at the time of writing from an allocation of 3,200.
The Bees have not faced the Magpies in 15 years when a Craig Bellamy extra time hat-trick gave the Tynesiders a 4-1 win over the west Londoners in the League Cup.
Hall of fame striker Lloyd Owusu scored the opening goal for Steve Coppell's side before Shola Ameobi spared Sir Bobby Robson's blushes.
Brentford last travelled to St James' Park for a league game in March 1993 and Newcastle emerged 5-1 winners to complete the double after winning 2-1 at Griffin Park in October 1992.
The last time the Bees triumphed over the Magpies was in 1948 when they won 1-0 at Griffin Park and their only win in the north east came in September 1934 where they won 5-2.
Newcastle United Fixtures
Sat 15th October
Brentford (H)
Tue 18th October
Barnsley (A)
Sat 22nd October
Ipswich Town (H)
Tue 25th October
EFLC Preston North End (H)
Sat 29th October
Preston North End (A)
ROTHERHAM 0 NEWCASTLE 1 (Atsu)
Darlow, Anita, Lascelles, Clark, Dummett, Atsu (67' Ritchie), Shelvey, Colback, Gouffran, Diame (87' Hanley), Gayle (79' Mitrovic)
Subs: Hayden, Mbemba, Yedlin, Sels
NEWCASTLE 4 NORWICH 3 (Gayle 3, Gouffran)
Darlow, Yedlin, Lascelles, Clark, Dummett (92 Atsu), Ritchie, Shelvey, Colback (71' Hayden), Gouffran, Diame (71' Mitrovic), Gayle
Subs: Lazaar, Perez, Mbemba, Sels
ASTON VILLA 1 NEWCASTLE 1 (Elphick og)
Sels, Yedlin (75' Tiote), Lascelles, Clark, Dummett, Ritchie, Hayden, Shelvey, Gouffran, Diame, Gayle (80' Mitrovic)
Subs: Hanley, Lazaar, Perez, Darlow, Atsu
LC NEWCASTLE 2 WOLVES 0 (Ritchie, Gouffran)
Darlow, Yedlin, Hanley, Clark, Lazaar, Shelvey, Colback, Ritchie (86' Lascelles), Diame (72' Perez), Gouffran (75' Atsu), Murphy
Subs: Dummett, Hayden, Woodman, Mitrovic
NEWCASTLE UTD 0 WOLVES 2
Sels, Anita, Mbemba, Lascelles, Dummett, Hayden (Mitrovic 62) Shelvey, Ritchie (Atsu 63), Diame, Perez, Gayle
Subs not used: Clark, Colback, Gouffran, Yedlin, Darlow
QPR 0 NEWCASTLE 6 (Shelvey 2, Perez, Clark, Mitrovic, Hanley)
Sels, Anita, Lascelles, Clark, Dummett (65' Hanley), Gouffran (61' Atsu), Hayden, Shelvey, Ritchie, Perez, Mitrovic (74' Yedlin)
Subs: Colback, Gayle, Diame, Darlow
DERBY CO 0 NEWCASTLE 2 (Gouffran, Yedlin)
Sels, Anita, Mbemba, Lascelles, Dummett, Ritchie, Shelvey, Colback, Gouffran (73' Yedlin), Diame (88' Hayden), Gayle (76' Perez)
Subs: Clark, Lazaar, Darlow, Mitrovic
NEWCASTLE 2 BRIGHTON 0 (Lascelles, Shelvey)
Sels, Anita (72' Gamez), Mbemba, Lascelles, Dummett, Ritchie, Hayden, Shelvey, Gouffran (88' Yedlin), Diame (81' Colback), Perez
Subs: Clark, Hanley, Darlow, Armstrong
(LC) NEWCASTLE 2 CHELTENHAM 0 (Perez 2)
Darlow, Sterry, Lascelles, Hanley, Gamez, Aarons (24' Gouffran), Shelvey, Colback, Perez, Diame, Mitrovic (38' Gayle)
Subs: Dummett, Hayden, Mbemba, Sels
BRISTOL CITY 0 NEWCASTLE 1 (Gayle)
Sels, Anita, Mbemba, Lascelles, Clark, Ritchie, Hayden (87' Shelvey), Colback, Gouffran, Diame (63' Perez), Gayle (88' Aarons)
Subs: Dummett, Hanley, Darlow, Sterry
NEWCASTLE 4 READING 1 (Hayden, Ritchie (P), Gayle 2)
Sels, Anita, Mbemba, Clark, Dummett, Hayden, Shelvey, Ritchie (90' Aarons), Perez (76' Lascelles), Gouffran (84' Colback), Gayle
Subs: Hanley, Janmaat, Darlow, Armstrong
NEWCASTLE 1 HUDDERSFIELD 2 (Gayle)
Sels, Janmaat (83' Armstrong), Mbemba, Lascelles, Dummett, Anita, Hayden, Shelvey, Aarons (45' Ritchie), Diame (75' Perez), Gayle
Subs: Clark, Colback, Darlow, Gamez
FULHAM 1 NEWCASTLE 0
Sels; Janmaat, Lascelles, Hanley, Dummett; Hayden (Shelvey 77), Colback (Aarons 61); Ritchie, Perez (Armstrong 70), Anita; Gayle.
Subs Mbemba, Darlow, Jesus Gamez, Sterry.
NEWCASTLE 3 VITESSE ARNHEM 2 (Leerdam (og), Gayle, Colback)
Sels; Janmaat (Sterry, 74), Hanley (Gamez, 62), Lascelles, Dummett; Hayden (Saivet, 74), Colback (Shelvey, 62); Anita (Mitrovic, 74), Perez (Armstrong, 62), Ritchie (Aarons, 62); Gayle (Gouffran, 74). Subs not: Darlow, Tiote, Thauvin.
SOUTHEND UTD 0 NEWCASTLE 2 (Anita, Gouffran)
Darlow; Janmaat (Sterry 63), Mbemba (Hanley 63), Lascelles, Dummett; Hayden (Colback 63), Shelvey (Saivet 73); Anita (Thauvin 78), Perez (Mitrovic 73), Aarons (Gouffran 63); Gayle (Armstrong 63).
Sub not used: Sels.
SPORTING LOKEREN 0 NEWCASTLE 4 (Perez 2, Perez, Janmaat, Shelvey)
Sels (Darlow 72); Sterry (Gouffran 63), Mbemba (Saivet 72), Lascelles (Dummett 63), Anita (Gamez 46); Hayden (Shelvey 46), Colback (Tiote 72); Janmaat, Perez (Mitrovic 46), Aarons (Thauvin 63), Gayle (Armstrong 63).
Subs not used: None.
DONCASTER ROVERS 2 NEWCASTLE UTD 2 (Hayden, Perez)
Sels, Janmaat (Sterry, 45), Mbemba (Saivet, 65), Lascelles (Dummett, 45), Colback (Hayden, 45), Anita (Gamez, 45), Ritchie (Gouffran, 45), Aarons (Perez, 45), Shelvey (Wijnaldum, 79), Mitrovic (Gayle, 45), Armstrong (Thauvin, 60).
BOHEMIANS 0 NEWCASTLE 6 (Ritchie, Mitrovic, Gayle, Thauvin, Aarons, Wijnaldum)
Sels, Anita, Lascelles, Mbemba, Sterry, Aarons, Colback, Gouffran, Ritchie, Saivet, Mitrovic.
Subs: Darlow, Gamez, Dummett, Wijnaldum, Shelvey, Hayden, Perez, Gayle, Janmaat, Tiote, Thauvin.