The in-form centre back trained away from the first team squad last night with United physio Paul Ferris.
Would be a huge miss
It will be a concern for Graeme Souness given that our recent resurgence owes much to the defensive pairing of Jean-Alain Boumsong and Bramble.
With Boumsong cup-tied, the prospect of also losing the former Ipswich Town defender could prove decisive in the outcome of the tie.
Meanwhile, Shola Ameobi sat out of last night’s session with a hip injury.