The Professional Development League fixture (7pm kick-off) gives both players a run out before being considered for Alan Pardew's first team squad on Monday at Goodison Park.
Ameobi has recovered from a hamstring injury.
NEWCASTLE UNITED UNDER-21 SQUAD: Alnwich, Mitchell, Nicholson, Riley, Logan, McKinnon, Good, Newton, Richardson, Knight, Inman, Hooper, Campbell, Sammy Ameobi, Gilliead.