Liverpool 2-1 Tottenham
Arsenal 2-0 Reading
Bristol City 1-2 Hull City
Newcastle 6-0 Preston
Leeds 2-2 Norwich - AET, Leeds win 3-2 on penalties
Newcastle boss Rafael Benitez was refusing to dream of EFL Cup glory as he turned his attention back to the business of winning promotion to the Premier League after a 6-0 rout of Preston.
Wednesday night's quarter-final draw could yet hand the Spaniard a showdown with former club Liverpool, but he was thinking only of Saturday's Sky Bet Championship reunion with North End at Deepdale within minutes of the final whistle at St James' Park.
Benitez said: "I have to concentrate just on Preston on Saturday, wait and see what happens in the draw and after, maybe I can answer those questions."
Championship leaders Newcastle romped to a 6-0 win over 10-man Preston at St James' Park.
Aleksandar Mitrovic put the Magpies ahead on 19 minutes with a powerful header at the back post.
Preston were reduced to 10 men on 27 minutes when midfielder Alan Browne was shown a red card for an elbow on Newcastle midfielder Jack Colback, who had to go off with a head injury.
Mo Diame made it 2-0 on 38 minutes with his first goal since signing from Hull, with Matt Ritchie adding a third from the penalty spot on 53 minutes.
Mitrovic got his second of the night and a fourth for the home side just two minutes later, with Diame also netting a brace following a 25-yard drive with three minutes to go.
There was still time for subsitite Ayoze Perez to add a sixth as Rafael Benitez side coasted into the quarter-finals.
Daniel Sturridge scored twice as Liverpool beat Tottenham 2-1 at Anfield to take their place in the quarter-finals of the EFL Cup.
Both sides made the expected sweeping changes for the fourth-round tie, which included a debut for 18-year-old Liverpool defender Trent Alexander-Arnold while midfielder Georges-Kevin Nkoudou and defender Cameron Carter-Vickers started for Spurs.
The Reds took an early lead through Sturridge on nine minutes when the England forward converted a cross from 20-year-old Serbian midfielder Marko Grujic.
Sturridge was on target again after 64 minutes when he latched onto a pass from Georginio Wijnaldum and beat Spurs stand-in keeper Michel Vorm.
Tottenham reduced the deficit with 14 minutes left when Vincent Janssen converted a penalty after a foul by Lucas on Erik Lamela.
Sturridge was denied a hat-trick by the crossbar as Jurgen Klopp's men progressed to the last eight.
Fellow Premier League pacesetters Arsenal are also through after beating Reading 2-0 at the Emirates Stadium, with another young side selected by manager Arsene Wenger.
Alex Oxlade-Chamberlain put the Gunners ahead on 33 minutes, after a mistake from Royals keeper Ali Al Habsi.
The result was put beyond the Sky Bet Championship side when Oxlade-Chamberlain got another on 78 minutes, via a deflection.
Hull made it into the quarter-finals with a 2-1 win at Bristol City.
Harry Maguire headed the Premier League side in front from a corner just before half-time.
It was 2-0 only two minutes into the second half when Michael Dawson nodded in from another Hull corner.
The Championship side netted a late consolation through a fine individual effort from substitute Lee Tomlin before Tammy Abraham saw an effort cleared off the line in the closing moments.
Sky Bet Championship side Leeds held their nerve in a penalty shoot-out to beat Norwich 3-2 on spot kicks after a 2-2 draw at Elland Road.
Alex Pritchard had given the visitors a first-half lead only for Marcus Antonsson to equalise just before the break.
Nelson Oliveira restored the Canaries advantage in extra-time but up popped Chris Wood with 11 minutes remaining to force a shoot-out, which Leeds won 3-2 to send the home crowd wild.