Man United have been tagged at 21/20 with William Hill to get three points, while Newcastle have odds of 3/1 in their own backyard.
Louis van Gaal’s side lost their last away game in the Premier League at Swansea City, but it was their only defeat in nine matches.
Eleven-goal No 9 Cisse goes into the game on a high after scoring against Aston Villa on Saturday, and told the Chronicle: “All the players are happy to be playing in this game.
“It is Manchester United – it’s a great fixture to be involved in and we are all looking forward to it.”
But Cisse feels that Newcastle must step up their quality levels from the Aston Villa game.
Victory against Man United would push them within two points of the 40-point mark many consider necessary to guarantee top-flight safety.
Cisse said: “It’s a big game, but it won’t be easy.
“We had to get ready quickly to be fresh from the Aston Villa game – the matches are coming quickly.”