Taylor (hamstring) and Coloccini (groin) both missed Saturday's 1-0 Championship defeat at Nottingham Forest and are not expected to recover in time for the trip to Glanford Park.
However, while Taylor will also struggle to make Saturday's home clash with Doncaster, the Argentina international is expected to be fit after almost a month on the sidelines.
Elsewhere, Chris Hughton has only long-term injury victims Shola Ameobi and Joey Barton missing, both with long-term foot problems as the Magpies attempt to bounce back from a run of three games which has seen them take just two points and slip from the top if the table as a result.