The Argentine defender has been out of action with a hamstring injury and was badly missed in Tuesday night's 3-0 defeat at Derby.
Chris Hughton: "Fabricio will be fine for Swansea.
"That's a boost because he has been a consistent performer this season."
Ryan Taylor is expected to shake off a hamstring problem, but veteran midfielder Nicky Butt will remain absent with a thigh problem.
New signings Mike Williamson and Fitz Hall have been paired together at the heart of the Newcastle defence in Coloccini's absence, so we will have to wait and see who makes way.