The France international featured in Arsenal's 4-1 win over Galatasaray in midweek after three months on the sidelines with an ankle injury.
Debuchy suffered the problem during the match against Manchester City in September, but is set to return to Premier League action against the side he left to move to the Emirates in the summer.
Arsene Wenger is almost certain to play Debuchy at the heart of the Arsenal defence for the visit of Alan Pardew's side because Laurent Koscielny is still out with a calf injury and Nacho Monreal is unavailable due to a foot problem.
Calum Chambers is also suspended after his red card against Stoke leaving Per Mertesacker as the only remaining senior central defender.
If Debuchy plays at centre-half, he will face former team-mate Papiss Cisse who is in blistering form since coming back from injury.
If you fancy a bet ... Cisse for first goalscorer.