Emre Injury Big Blow
The midfielder only lasted 26 minutes in the 3-1 defeat by Bulgaria in Sofia after sustaining the injury and could also miss the game with Bolton in midweek.
He had treatment in Istanbul while his team-mates flew back to Newcastle straight after the match.
Souness had harsh words to say before his players flew out to play friendly internationals calling the games "Mickey Mouse fixtures we don't need at this time of the season".
James Milner came through the England Under-21 match unscathed on Tuesday, while Jermaine Jenas only played the final seven minutes of last night's full international in Denmark.
Shay Given was man of the match as the Republic of Ireland were beaten 2-1 by Italy in Dublin, with Stephen Carr playing the last 57 minutes.
Jean Alain Boumsong played the full 90 minutes in the 3-0 victory over the Ivory Coast in Montpelier.
Amady Faye was involved in Senegal's goalless draw with Ghana at Brentford's Griffin Park.
Hugo Viana played for 62 minutes as Portugal beat Egypt in the Azores.