Manchester City's home clash against Fulham on February 4 will be shown on ESPN on Freeview as part of a taster weekend during which the subscription channel will be available for all viewers.
Since the inception of the Premier League in 1992, all Premier League football has been broadcast in the UK on pay TV channels.
The weekend's coverage will also include live Serie A and Bundesliga football.
"This is a great opportunity for us to introduce that to millions more and let them sample the programming ESPN has on offer," ESPN chief Jeroen Oerlemans said.