Hugo Viana has recovered from his knee problem and will start on the left, with a fit again Laurent Robert on the bench.
Nobby Solano also looks set for a recall on the right, with Jermaine Jenas the man to miss out.
Sir Bobby will let Craig Bellamy and Andy Griffin decide whether or not they are fit enough to play, with Shola Ameobi and Olivier Bernard on stand-by.
Probable team: Given; Hughes, Griffin, Dabizas, O’Brien; Viana, Solano, Dyer, Speed; Shearer, Bellamy. Subs: Harper, Bernard, Caldwell, Robert, Jenas, Ameobi, Lua Lua.
Inter coach Hector Cuper is without Nelson Vivas and Sergio Conceciao, but will recall Argentinian internationals Hernan Crespo and Javier Zanetti after they were rested for the Milan derby at the weekend.
Alvaro Recoba and Luigi di Biagio also look set to be left on the bench.
Probable team: Toldo; Zanetti, Materazzi, Cannavaro, Cordoba; Okan, Emre, Dalmat, Morfeo; Crespo, Vieri. Subs: Fontana, Coco, Di Biagio, Almeyda, Gamarra, Recoba, Kallon.