Ryan Mason and Sam Clucas will miss Hull's EFL Cup quarter-final against Newcastle.
Midfielder Mason has not recovered from the illness which forced him off at half-time during Saturday's 1-1 draw with West Brom while forward Clucas is suspended after collecting his fifth yellow card of the season in the same game.
Tigers head coach Mike Phelan may be tempted to hand defender Andrew Robertson and striker Adam Diomande starts after the pair were second-half substitutes against the Baggies following their returns from injury and suspension respectively.
Newcastle boss Rafael Benitez is likely to make changes once again.
Defender Jesus Gamez will miss the game as he faces up to the prospect of having to undergo surgery on the collarbone he damaged during Saturday's 1-0 Sky Bet Championship defeat by Blackburn, an injury that could keep him out of action for around six weeks.
Defender Grant Hanley is ready to return from a shin injury, while Jack Colback is available after recovering from an eye problem, as is fellow midfielder Jonjo Shelvey as he awaits a date for his personal hearing for a Football Association misconduct charge.
Benitez made six changes, only one of them enforced, for Saturday's game as DeAndre Yedlin, Gamez, Chancel Mbemba, Isaac Hayden, Christian Atsu and Aleksandar Mitrovic replaced Vurnon Anita, Paul Dummett, Jamaal Lascelles, Colback, Yoan Gouffran and Dwight Gayle.