The Barclays Premier League's bottom side failed to rouse themselves for a must-win game at the Etihad Stadium and seemed condemned after conceding Aguero's first after just four minutes.
Aleksandar Kolarov, James Milner and David Silva also got on the scoresheet as rampant City, who hit the woodwork as well through Wilfried Bony, kept up their challenge for second place with a fourth successive win.
But the story of the afternoon was about QPR's sorry demise after just one season back in the top-flight.
Questions will now be asked about the future of manager Chris Ramsey and, perhaps more seriously, the status of the club itself with the Football League's position over their financial situation still unclear.
QPR's sorry day began with administrative issues.
It emerged prior to the game that midfielder Sandro had been withdrawn on Home Office advice because of an issue relating to his UK residency visa.
Clint Hill, Steven Caulker and Bobby Zamora did at least pass fitness tests but once the game began, it seemed the visitors lacked heart for the battle.
Results on Saturday had sent the Londoners to the bottom of the table needing to win to have any hope of survival, but their body language never seemed right.
Newcastle's fight for Premier League survival continues at Loftus Road next Saturday, and surely there couldn't be an easier place to visit.