The Spanish left-back missed the 4-1 win over Blackpool with a virus but is back in contention for a starting place as the Magpies look to a move a step closer to securing the Championship title.
Manager Chris Hughton is being cautious regarding Enrique and told the club's official website: "We're hopeful he'll be fine but we'll see how he is."
Meanwhile, defender Tamas Kadar is out.
The young Hungarian deputised on the left side of defence in Enrique's absence but lasted only 37 minutes before picking up a hamstring strain.
Hughton could decide to freshen up his team so the likes of Shola Ameobi, Joey Barton and Alan Smith will be hoping for recalls.