The Geordie striker has netted seven times in the Tyne-Wear fixture - a haul bettered only by club legend Jackie Milburn.
He came off the bench to salvage a last-gasp 1-1 draw when the fierce foes met at St James' Park in March and has told boss Alan Pardew he is ready to deliver all three points this time around.
Shola Ameobi: "Hopefully, I can keep the (goalscoring) run going.
"It's something important to me, but a victory would mean so much to our supporters, and also to our season.
"We're all excited, and hopefully we come back with the three points.
"I worked so hard in pre-season to get myself right, and then I got injured just before the first game. I worked very hard to come back and now I feel that my game is right where I want it.
"I feel that whenever I'm called upon, I can do a great job for the team. It's up to the manager who he picks, but he knows I'm ready to rock and roll.
"I'm fit and looking to play more games. I'm as hungry as ever."