Chelsea are home to Bolton on the final day on Sunday while Sir Alex Ferguson's side go to Wigan. Then they clash in the Champions League final in Moscow.
Avram Grant: "From day one our target was to be in the Champions League final and to improve our game.
"We've done more than I even expected, so we want to believe the season will end well and we will fight to the last minute.
"United have had a fantastic season. They've been champions many times before but this year we have given them a good battle and it is not finished yet.
"Even if they win the title on goal difference you must give my team respect.
"For more than 30 years I've visited English football, at least five times a year since I was a boy.
"Even when I didn't have much money I came here. One thing I like is that you play football until the end, not like other countries.
"Sometimes I'm too positive and too optimistic, but I believe in the traditions of English football.
"We need to win first and it's not easy for them to play at Wigan.
"I don't believe that Bruce will give the game to Manchester United.
"Maybe we can win 18-0 on Sunday, if we play against a team that will let us to. I don't think so, though.
"Wigan will do the Premier League justice and they will go out there wanting to beat Manchester United.
"Hopefully they will do. We have worked out socks off all year, so it will be disappointing if they don't.
"We saw the likes of many teams yesterday putting out full-strength teams and really going for it against some teams who have got nothing to go for.
"Wigan are safe now - hopefully, with a great manager like Steve Bruce, they are going to go for it.
"We have still got a tough game at home to Bolton, but if we pick up the three points, as we did today, we have got a very good chance."