The Australian international, who joined United from Borussia Moenchengladbach in the summer, was making his first competitive start for the club after shaking off a hamstring injury picked up in the final pre-season friendly game at Bray Wanderers.
With Titus Bramble still on the sidelines with a similar injury, Moore had been hoping to play himself into contention for a place in the squad for Sunday's Tyne-Wear derby.
But the former Rangers centre-back pulled up seconds before the half-time whistle. To cap a miserable evening for the Magpies' second string, goals from Andrew Barrowman and Neil Kilkenny saw Tommy Craig's men make the trip home empty-handed.