The Red Devils will be looking to kick on from their 2-0 win at Huddersfield last week, as Jose Mourinho comes up against his old adversary Rafa Benitez.
It could be a tough game for United, as while Newcastle are enduring a poor season, Mourinho has a terrible record on Tyneside, losing three and drawing three of his six visits.
Eric Bailly (ankle), Zlatan Ibrahimovic (knee) and Daley Blind (knock) are all nearing a return to first team action, but are unlikely to feature here.
Meanwhile, Marouane Fellaini is suffering from a serious knee injury and might not return before April.
Marcus Rashford is a slight doubt following a muscle problem he picked up against Huddersfield, but could still play a part.
Mourinho dropped Paul Pogba, Ashley Young, Anthony Martial and Phil Jones for that game, but we are expecting a couple of those players to return on Sunday.