Martins had a scan on Thursday night after making his comeback from a groin problem in Wednesday's Carling Cup defeat by Tottenham, and joins fellow frontmen Mark Viduka, Alan Smith and Andy Carroll on the casualty list ahead of Saturday's clash.
Midfielder Ignacio Gonzalez is also out with an Achilles injury, while Danny Guthrie and Joey Barton are still suspended and Habib Beye (Achilles), Jonas Gutierrez (shoulder) and Jose Enrique are also missing.
Jason Brown will be in goal for Blackburn in Saturday's Barclays Premier League match at Newcastle.Brown steps in with England goalkeeper Paul Robinson out for two weeks with a calf injury sustained in the midweek Carling Cup defeat of Everton.
Rovers are also without Vince Grella (calf), Steven Reid (knee) and David Dunn (Achilles), while Benni McCarthy (groin) and Aaron Mokoena (virus) are doubtful.
However, midfielder Keith Andrews is available again after missing the Everton match as he was ineligible.
NEWCASTLE (from): Given, Harper, Edgar, N'Zogbia, Taylor, Coloccini, Cacapa, Bassong, Tozer, Butt, Geremi, Duff, Donninger, Owen, Xisco, Ameobi, Donaldson, Ranger, Danquah.
BLACKBURN (from): Brown, Bunn, Simpson, Ooijer, Samba, Nelsen, Khizanishvili, Warnock, Olsson, Emerton, Villanueva, Tugay, Mokoena, Andrews, Pedersen, Treacy, Santa Cruz, Roberts, Derbyshire, McCarthy, Fowler.