The Spaniard made four changes for Tuesday night's 6-0 rout at QPR with Ciaran Clark, Isaac Hayden, Ayoze Perez and Aleksandar Mitrovic replacing Chancel Mbemba, Jack Colback, Mohamed Diame and Dwight Gayle.
Colback was an unused substitute at Loftus Road having overcome a hamstring strain, while Yoan Gouffran started despite concerns over a hip problem.
Central defender Mbemba missed out with a slight knock but is expected to be fit for the weekend, and that means Benitez will be missing only long-term absentees Rob Elliot and Rolando Aarons, while Massadio Haidara continues his quest for match fitness after recovering from a knee injury which has sidelined him for 11 months.
Wolves boss Walter Zenga is likely to make wholesale changes after accusing his players of giving up in their 4-0 home defeat to Barnsley.
The manager is yet to name an unchanged side this season and Dave Edwards and Cameron Borthwick-Jackson could return while Romain Saiss, Silvio and Ola John are waiting to make their debuts.
Nouha Dicko is closing in on a comeback from a knee injury after being out for a year but he has returned to training.
Mike Williamson (glute) is out until 2017 while Michal Zyro and Jordan Graham remain sidelined with long-term knee injuries.
QPR 0 NEWCASTLE 6
Sels, Anita, Lascelles, Clark, Dummett (65' Hanley), Gouffran (61' Atsu), Hayden, Shelvey, Ritchie, Perez, Mitrovic (74' Yedlin)
Subs: Colback, Gayle, Diame, Darlow
Jonjo Shelvey scored twice as Newcastle hammered QPR 6-0 in a totally one-sided game at Loftus Road - Rangers' heaviest-ever home league defeat.
There were also goals for Ayoze Perez, Ciaran Clark, Aleksandar Mitrovic and Grant Hanley as the Magpies, who were twice denied by the woodwork, stormed to their fifth consecutive win.
They went ahead in the 12th minute, when Shelvey's shot took a deflection off Karl Henry, wrongfooting keeper Alex Smithies.
And they doubled their lead on the half-hour mark when Perez collected Matt Ritchie's delivery and scored at the second attempt after his first effort had been blocked by keeper Smithies.
Shelvey's second came three minutes into the second half and was a beauty, the midfielder curling a glorious shot into the top corner of the net from 25 yards.
Clark made it four with a header from Ritchie's 56th-minute corner from the right.
Nine minutes later, Perez attempted to nudge substitute Christian Atsu's shot towards goal and inadvertently teed up Mitrovic, who finished from seven yards out.
And when Clark's scuffed volley on 79 minutes dropped to an unmarked Hanley, he fired home to complete the rout.
Newcastle dominated from the start and thought they had gone ahead when Shelvey's shot was diverted into the net by Perez, but the Spaniard was offside.
It was only a temporary reprieve for QPR, who switched off and were punished when Mitrovic broke down the left following Ritchie's quickly-taken throw and found Shelvey, whose shot ended up in the net.
A goal down and being completely outclassed, there was more trouble for Rangers when James Perch, playing against his former club, was stretchered off with what looked like a knee injury following a challenge near the halfway line.
Perch, who was replaced by debutant Pawel Wszolek, had been deployed on the right of midfield in a 4-4-1-1 formation adopted by Rangers boss Jimmy Floyd Hasselbaink in an attempt to contain Newcastle's attacking threat.
But there was no stopping Rafael Benitez's side, who somehow managed to dominate the second half even more than they did the first.
Shelvey's strike and Clark's goal put them in total control before Smithies temporarily denied them a fifth goal by tipping Mitrovic's header from Isaac Hayden's cross on to the bar.
Mitrovic eventually netted and Hanley's goal condemned QPR to their heaviest home loss since Arsenal beat them by the same scoreline in an FA Cup tie in 2001.
And it was nearly seven - Atsu blasted against the underside of the bar in the final minute after the outstanding Perez had pulled the ball back from the left.
QPR 0 NEWCASTLE 6 (Shelvey 2, Perez, Clark, Mitrovic, Hanley)
Sels, Anita, Lascelles, Clark, Dummett (65' Hanley), Gouffran (61' Atsu), Hayden, Shelvey, Ritchie, Perez, Mitrovic (74' Yedlin)
Subs: Colback, Gayle, Diame, Darlow
DERBY CO 0 NEWCASTLE 2 (Gouffran, Yedlin)
Sels, Anita, Mbemba, Lascelles, Dummett, Ritchie, Shelvey, Colback, Gouffran (73' Yedlin), Diame (88' Hayden), Gayle (76' Perez)
Subs: Clark, Lazaar, Darlow, Mitrovic
NEWCASTLE 2 BRIGHTON 0 (Lascelles, Shelvey)
Sels, Anita (72' Gamez), Mbemba, Lascelles, Dummett, Ritchie, Hayden, Shelvey, Gouffran (88' Yedlin), Diame (81' Colback), Perez
Subs: Clark, Hanley, Darlow, Armstrong
(LC) NEWCASTLE 2 CHELTENHAM 0 (Perez 2)
Darlow, Sterry, Lascelles, Hanley, Gamez, Aarons (24' Gouffran), Shelvey, Colback, Perez, Diame, Mitrovic (38' Gayle)
Subs: Dummett, Hayden, Mbemba, Sels
BRISTOL CITY 0 NEWCASTLE 1 (Gayle)
Sels, Anita, Mbemba, Lascelles, Clark, Ritchie, Hayden (87' Shelvey), Colback, Gouffran, Diame (63' Perez), Gayle (88' Aarons)
Subs: Dummett, Hanley, Darlow, Sterry
NEWCASTLE 4 READING 1 (Hayden, Ritchie (P), Gayle 2)
Sels, Anita, Mbemba, Clark, Dummett, Hayden, Shelvey, Ritchie (90' Aarons), Perez (76' Lascelles), Gouffran (84' Colback), Gayle
Subs: Hanley, Janmaat, Darlow, Armstrong
NEWCASTLE 1 HUDDERSFIELD 2 (Gayle)
Sels, Janmaat (83' Armstrong), Mbemba, Lascelles, Dummett, Anita, Hayden, Shelvey, Aarons (45' Ritchie), Diame (75' Perez), Gayle
Subs: Clark, Colback, Darlow, Gamez
FULHAM 1 NEWCASTLE 0
Sels; Janmaat, Lascelles, Hanley, Dummett; Hayden (Shelvey 77), Colback (Aarons 61); Ritchie, Perez (Armstrong 70), Anita; Gayle.
Subs Mbemba, Darlow, Jesus Gamez, Sterry.
NEWCASTLE 3 VITESSE ARNHEM 2 (Leerdam (og), Gayle, Colback)
Sels; Janmaat (Sterry, 74), Hanley (Gamez, 62), Lascelles, Dummett; Hayden (Saivet, 74), Colback (Shelvey, 62); Anita (Mitrovic, 74), Perez (Armstrong, 62), Ritchie (Aarons, 62); Gayle (Gouffran, 74). Subs not: Darlow, Tiote, Thauvin.
SOUTHEND UTD 0 NEWCASTLE 2 (Anita, Gouffran)
Darlow; Janmaat (Sterry 63), Mbemba (Hanley 63), Lascelles, Dummett; Hayden (Colback 63), Shelvey (Saivet 73); Anita (Thauvin 78), Perez (Mitrovic 73), Aarons (Gouffran 63); Gayle (Armstrong 63).
Sub not used: Sels.
SPORTING LOKEREN 0 NEWCASTLE 4 (Perez 2, Perez, Janmaat, Shelvey)
Sels (Darlow 72); Sterry (Gouffran 63), Mbemba (Saivet 72), Lascelles (Dummett 63), Anita (Gamez 46); Hayden (Shelvey 46), Colback (Tiote 72); Janmaat, Perez (Mitrovic 46), Aarons (Thauvin 63), Gayle (Armstrong 63).
Subs not used: None.
DONCASTER ROVERS 2 NEWCASTLE UTD 2 (Hayden, Perez)
Sels, Janmaat (Sterry, 45), Mbemba (Saivet, 65), Lascelles (Dummett, 45), Colback (Hayden, 45), Anita (Gamez, 45), Ritchie (Gouffran, 45), Aarons (Perez, 45), Shelvey (Wijnaldum, 79), Mitrovic (Gayle, 45), Armstrong (Thauvin, 60).
BOHEMIANS 0 NEWCASTLE 6 (Ritchie, Mitrovic, Gayle, Thauvin, Aarons, Wijnaldum)
Sels, Anita, Lascelles, Mbemba, Sterry, Aarons, Colback, Gouffran, Ritchie, Saivet, Mitrovic.
Subs: Darlow, Gamez, Dummett, Wijnaldum, Shelvey, Hayden, Perez, Gayle, Janmaat, Tiote, Thauvin.