The Argentina international was well short of class in the top flight the last time he strutted his stuff.
So all eyes will be on him.
Coloccini and Xisco cost Newcastle a combined fee of £15.7m for the pair, and both were the subject of attention from the Spanish media on arrival in La Coruna last night.
Chris Hughton: “I think they will all be up for it, not just Colo and Xisco, but going there will mean something to Jose Enrique as well.
“It’ll be a good moment for them to be back in Spain. It’ll give them the opportunity to see some old faces and so on.
“That’s the nice bit, but the most important bit is getting the result we need and coming through the game having taken something from it.
“It’s another step nearer the first game at Man United.
“Colo had a very, very good season, along with the other players. It’s important he carries that form into the Premier League season.
“He was a foreign player coming to England two years ago, and the settling-in period is never easy.
“But now it’s about him and the other players maintaining the form that they showed last seaason.”