The Bulgaria international picked up a hamstring injury during Wednesday's 3-2 win against Blackburn and will be given a late fitness test with Steve Sidwell on stand-by to replace him.
Sidwell has yet to start a Premier League game for Villa having been troubled by injury since his £5million summer switch from Chelsea.
Manager Martin O'Neill must also decide whether to recall striker John Carew to the starting line-up.
The Norway international has started the last two games on the bench after missing the UEFA Cup tie against Ajax through illness.
ASTON VILLA (from): Friedel, L Young, Laursen, Knight, Davies, Cuellar, Shorey, Milner, Routledge, Petrov, Reo-Coker, Sidwell, Barry, A Young, Carew, Agbonlahor, Harewood, Gardner, Salifou, Osbourne, Guzan.