Aston Villa, Sunderland and Norwich are in the Premier League relegation places after Saturday''s action and the trio are all odds-on for the drop with Sky Bet.
Bottom-of-the-table Villa beat Norwich 2-0 and that allowed Newcastle to move above the Canaries with a 1-0 victory at home to West Brom.
Leicester are now 15/8 favourites with Sky Bet for the Premier League after they swept aside Manchester City 3-1 - a result which scooped one punter £10,000 off a £10 scorecast bet.
The remarkable story for Claudio Ranieri''s 5,000/1 pre-season shots continued with a thoroughly convincing display and it has seen them move to the head of the market at 15/8 having been on offer a 5/1 prior to kick-off.
Two goals from Robert Huth and another from Riyad Mahrez put the visitors well in control before Sergio Aguero netted a late consolation with three minutes to play.
That Aguero goal will have been widely celebrated by one Sky Bet punter in particular who won a massive £10,000 off a £10 bet on Huth to score first in a 3-1 away win at 1,000/1.
Barclays Prem
Liverpool 2 - 2 S''land
A Villa 2 - 0 Norwich
Man City 1 - 3 Leicester
Newcastle 1 - 0 W Brom
Stoke 0 - 3 Everton
So''ton 1 - 0 West Ham
Tottenham 1 - 0 Watford
Swansea 1 - 1 C Palace
That is not the only big hit Sky Bet could take on Leicester this season as 20 punters with the firm could win a combined £5million if Leicester hold on to top spot.
One punter placed a £40 bet on at odds of 5,000/1 and now stands to make £200,000 if the Foxes still hold sway in May.
City are now 3/1 chances with Arsenal on offer at 11/4.
Tottenham are the side sitting five points behind Leicester in second after a 1-0 victory at home to Watford but Mauricio Pochettino''s men are fourth in the title betting at 4/1.
Barclays Prem
1 Leicester 53
2 Tottenham 48
3 Man City 47
4 Arsenal 45
5 Man Utd 40
6 West Ham 39
7 So''ton 37
8 Everton 35
9 Liverpool 35
10 Watford 33
11 Stoke 33
12 C Palace 32
13 Chelsea 29
14 W Brom 29
15 B''mouth 28
16 Swansea 27
17 Newcastle 24
18 Norwich 23
19 S''land 20
20 A Villa 16