Manager Chris Hughton has been dealt a further blow by the absence of Ryan Taylor, who would have been one of the candidates to replace Barton, with an ankle injury.
Shola Ameobi will undergo a late fitness test of the hamstring he damaged during the midweek defeat by Blackburn, while James Perch will hope to shake off an ankle problem and Leon Best (also ankle) is back in training.
Steve Harper (shoulder), Hatem Ben Arfa (double leg fracture) and Dan Gosling (knee) remain on the casualty list.
NEWCASTLE (from): Krul, Soderberg, Simpson, Perch, Ferguson, Enrique, Coloccini, Williamson, S. Taylor, Campbell, Kadar, Smith, Tiote, Routledge, Gutierrez, Guthrie, Vuckic, Tavernier, Donaldson, Nolan, Carroll, Ameobi, Lovenkrands, Ranger, Xisco.
Fulham have no fresh injury concerns for Saturday's Barclays Premier League game at Newcastle.
Mexican defender Carlos Salcido remains sidelined for more than a fortnight with ankle ligament damage.
The Cottagers will also be missing defender Chris Baird (thigh) but he could return for next weekend's match against Manchester City.
FULHAM (from): Schwarzer, Kelly, Hangeland, Hughes, Duff, Davies, Greening, A Johnson, Murphy, Gera, Dembele, Dempsey, Stockdale, Pantsil, Etuhu, E Johnson, Briggs, Dikgacoi.