Goals from Yossi Benayoun, Dirk Kuyt and substitute Lucas leave the Magpies needing to win their clash with relegation rivals Middlesbrough if they are to stand any chance of staying in the top-flight.
Liverpool manager Rafa Benitez left star striker Fernando Torres out of the squad for the clash, as Dirk Kuyt assumed the lone striker role with the returning Steven Gerrard in support.
Anfield old boy Michael Owen was sacrificed from the three-man Newcastle attack that failed to score against Portsmouth in their last outing, as Mark Viduka and Obafemi Martins were given the task of breaking Liverpool's stern defence.
The Reds' ability to record high scores in recent weeks has been down to their blistering starts to games, but Newcastle held their ground well in the early stages.
Gerrard's long-range effort after 15 minutes brought the best out of Newcastle keeper Steve Harper.
Peter Lovenkrands should have given Shearer's side the lead after rounding Jose Reina though, but his effort was eventually cleared.
With Benitez barking orders from the sidelines, Liverpool changed up a gear and started showing the class that has thrilled the Anfield faithful this season, as they hit Shearer's side with two goals in six minutes.
Newcastle striker Viduka inexplicably headed the ball back into his own area and could only head the ball straight to Kuyt on the right wing. The Dutchman sent in the cross and with a hint of offside, Benayoun slotted home from close range.
Newcastle could blame nobody but themselves when the second came on 28 minutes though as poor marking allowed Kuyt to head home from Gerrard's pinpoint corner.
The away side were in disarray and Shearer could only look on as Xabi Alonso hit the crossbar and Daniel Agger hit a thunderous effort from 30 yards which Harper tipped away.
Shearer was renowned for getting the best out of his team-mates when he was a player, but whatever he said to his team at half-time made little difference as Liverpool continued to press for a third goal.
Spanish winger Albert Riera should have done better with a header, while Gerrard and Javier Mascherano shot wide.
Newcastle were lucky not to be down to ten men on the hour mark after fiery midfielder Alan Smith lunged in on Reds' full-back Alvaro Arbeloa, but referee Phil Dowd only produced a yellow.
Joey Barton wasn't so lucky though and he was given a straight red card after a horrendous two-footed tackle on Alonso.
It got from bad to worse for Newcastle though, as Lucas came off the bench to power home a header from Fabio Aurelio's free-kick.